Scientists at Queen Mary, University of London have made an important discovery in understanding what causes arteries to clog up.
They have discovered that an enzyme called matrix metalloproteinase-8 plays a crucial role in raising blood pressure and causing abnormal build-up of cells in the arteries – both of which increase the risk of heart disease.
Heart disease is the number one cause of death in the UK. The scientists say that their research could lead to new drugs for treating high blood pressure and preventing heart disease.
Shu Ye, Professor of Molecular Medicine and Genetics at Queen Mary, University of London led the study. He explained: "Our research tells us that this enzyme plays a crucial role in the build-up of fatty deposits in the arteries which causes heart disease.
"Many patients with high blood pressure or heart failure are currently treated with ACE inhibitor drugs. However, some patients do not respond sufficiently to ACE inhibitors alone. We hope that what we've found here could be the basis for new drugs that can enhance the effects of ACE inhibitors, which would reduce deaths from heart disease."
For complete article go to: http://www.sciencedaily.com/releases/2009/09/090924101625.htm
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